# Your Skin Loses 75% of This by Age 75 (New Fix)

## Метаданные

- **Канал:** Dr Brad Stanfield
- **YouTube:** https://www.youtube.com/watch?v=ZZKdBM7D-3k
- **Дата:** 18.03.2026
- **Длительность:** 11:12
- **Просмотры:** 26,467

## Описание

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Timestamps:
00:00 Hyaluronic Acid Problems
00:52 Studies on Hyaluronic Acid and Skin Health
02:46 Understanding Absorption of Hyaluronic Acid
05:14 New Findings on Absorption
07:00 New Clinical Trial on Hyaluronic Acid
08:44 Possible Mechanisms of Action
00:09:46 Key Takeaways

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Here are the links to the research papers referenced in the video:
https://www.sciencedirect.com/science/article/abs/pii/S0144861723003454?via%3Dihub
Molecular weight and gut microbiota determine the bioavailability of orally administered hyaluronic acid

https://www.nature.com/articles/s41598-025-32758-5
Oral sodium hyaluronate improves skin hydration, barrier function and signs of aging: a randomized, double-blind, placebo-controlled trial in 150 healthy adults

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522662/
Oral hyaluronan relieves wrinkles: a double-blinded, placebo-controlled study over a 12-week period

https://pmc.ncbi.nlm.nih.gov/articles/PMC4110621/
Ingested hyaluronan moisturizes dry skin

https://pubmed.ncbi.nlm.nih.gov/34933842/
Oral intake of a new full-spectrum hyaluronan improves skin profilometry and ageing: a randomized, double-blind, placebo-controlled clinical trial

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661223/
Oral administration of hyaluronic acid to improve skin conditions via a randomized double-blind clinical test, 2023

https://pmc.ncbi.nlm.nih.gov/articles/PMC10082573/
The Effectiveness of Injectable Hyaluronic Acid in the Improvement of the Facial Skin Quality: A Systematic Review

https://pubs.acs.org/doi/10.1021/jf8017029
Absorption, Uptake and Tissue Affinity of High-Molecular-Weight Hyaluronan after Oral Administration in Rats and Dogs

https://pmc.ncbi.nlm.nih.gov/articles/PMC3512263/
Oral Administration of Polymer Hyaluronic Acid Alleviates Symptoms of Knee Osteoarthritis: A Double-Blind, Placebo-Controlled Study over a 12-Month Period

Thumbnail by James Kelly
Video edited by Troy Young
Script by John Milliken

The links above are affiliate links, so I receive a small commission every time you use them to purchase a product. The content contained in this video, and its accompanying description, is not intended to replace viewers’ relationships with their own medical practitioner. Always speak with your doctor regarding the content of this channel, and especially before using any products, services, or devices discussed on this channel.

## Содержание

### [0:00](https://www.youtube.com/watch?v=ZZKdBM7D-3k) Hyaluronic Acid Problems

Here is the exact moment where the hyaluronic acid story to treat skin wrinkles looks like it comes crashing down. A groundbreaking 2023 study radioactively labeled hyaluronic acid in supplements to see if it's absorbed. And the study concluded that hyaluronic acid is broken down and is not absorbed in its intact form. So are supplement companies just lying to you about hyaluronic acid? Well, not so fast. Particularly when we factor in a new human randomized clinical trial that was published in the journal Scientific Reports in December 2025. So hyaluronic acid is a natural compound found especially in our skin, joints and eyes and it provides critical structural support in the skin. It tries to keep it plump and hydrated and smooth. But unfortunately levels of hyaluronic acid in the skin, they slowly decrease with age. So someone at the age of 75, for instance, only has one quarter of the amount of hyaluronic acid in their skin compared to someone who is 19 years old.

### [0:52](https://www.youtube.com/watch?v=ZZKdBM7D-3k&t=52s) Studies on Hyaluronic Acid and Skin Health

And there have been some encouraging studies showing that supplementing with hyaluronic acid may help to combat this decline. So for instance, there were several smaller studies in Japan focused on whether hyaluronic acid could improve dry skin and they consistently showed that hyaluronic acid supplements did improve skin moisture. And then there's the effect on wrinkles. A small initial study published way back in 2007 found that hyaluronic acid supplements taken for 8 weeks reduced wrinkles around the eyes. And several studies later backed up this finding. So for instance, a 2021 trial found that wrinkles decreased by 18. 8% 8% in the hyaluronic acid group compared to a non-significant reduction of 2. 6% in the placebo group. And then finally, a larger 2023 study of 129 people again demonstrated skin benefits from hyaluronic acid supplements in multiple different areas. But even though all of these results are encouraging, there have been some significant drawbacks with the existing studies that introduce some uncertainty. So for instance, the sample sizes as in how many people are included in these studies has been relatively small which decreases the confidence in the results. Participants have also had specific skin conditions like dry or aged skin and most of them have been in countries in Asia. So these factors make it unclear about what kinds of results we might see in other populations and some studies have lacked detailed statistical analysis making it hard to critically evaluate the findings. Plus many of the key studies they're only published in Japanese which in today's world with JGBT is not so much of an issue but historically it has been that accessibility and evaluation is an issue. And there's also important metrics related to skin quality that earlier studies have not checked. So these include the extent of water loss for instance through the skin. What's happening with oil production and the changes in skin coloration? And finally there's the issue of dosing. Many studies have used relatively high doses of hyaluronic acid, but there's emerging evidence that substantially lower doses might be just as effective. And on top

### [2:46](https://www.youtube.com/watch?v=ZZKdBM7D-3k&t=166s) Understanding Absorption of Hyaluronic Acid

of all of these limitations, there have been concerns about absorption, which is the key issue that I started this video with. So to see skin improvements, we want to target the rejuvenation of hyaluronic acid in the layers of the skin. So how do we make sure that hyaluronic acid in supplements actually reaches that target? Well, we could take a very direct route. So, hyaluronic acid, it can be injected directly into the skin. It is a popular cosmetic treatment and the evidence suggests that it does probably work. For instance, one recent meta analysis examined 13 studies on the procedure and the authors found that injecting hyaluronic acid causes significant improvements in skin facial quality. But we're interested in hyaluronic acid supplements since it's a lot more accessible for many of us. So, the question is whether hyaluronic acid that we swallow can actually make it to the skin where it's needed. And initially there was a big reason to think the answer would be no. So to see why we need to talk about molecular weight. So a molecule is just a collection of atoms that are bonded together in a certain way. And the weight is about how big that collection is. So structurally hyaluronic acid is a chain that's built from simple lengths. And just like a chain the molecules of hyaluronic acid can be different lengths. So long ones are heavy and they've got a high molecular weight. Short ones have got a low molecular weight. Scientists initially thought that high molecular weight forms of hyaluronic acid would be the best oral supplements. The idea was that they'd be more stable and less likely to be immediately broken down through digestion. Plus, they may have an anti-inflammatory effect. The hope was that they would be able to make it intact to sites in the skin where it would be useful. But there is a catch 22 here. Those high molecular weight forms of hyaluronic acid, they've got big molecules and may be too big to pass through the intestinal wall. And if that proved to be the case, then the fear was that the supplement would just pass through the digestive system without providing any benefits. So we didn't know for sure what would happen until we did some research. So the early experiments they were encouraging. A groundbreaking study published in 2009, for instance, involved hyaluronic acid supplements in rats and dogs. And the researchers used a high molecular weight form. So they tagged that hyaluronic acid with a radioactive substance so they could see exactly where it went and how it was absorbed. and they found evidence that it did make its way directly to the connective tissues throughout the bodies of the animals. So, it seemed to stay intact and make it through the gut barrier. Another study citing human experiments agreed with that animal conclusion. So, initially it looked like hyaluronic acid as an oral supplement was absorbed whole and then distributed to the skin. But that brings

### [5:14](https://www.youtube.com/watch?v=ZZKdBM7D-3k&t=314s) New Findings on Absorption

us back to that 2023 study that I mentioned at the start of this video. It revealed that our assumptions about how hyaluronic acid worked as a supplement were completely wrong. First, high molecular weight hyaluronic acid is not absorbed at all. It doesn't mean that nothing gets absorbed, but the story is far more complex than we initially thought. So, the high molecular weight hyaluronic acid, it first has to be broken down and that happens in the stomach as those long chains get chopped up into shorter lengths. But here's where it gets interesting. Those shorter lengths called middleweight hyaluronic acid, they aren't absorbed either. So, for this study, the researchers used two kinds of mice. One group had a normal gut bacteria and the other group had no gut bacteria. In the no gut bacteria group, no hyaluronic acid whatsoever was absorbed. It was broken down in the stomach and then it just passed straight through these animals. In the other group with the normal bacteria, however, things went differently here. The mediumweight hyaluronic acid got broken down even further by the gut bacteria. And this finally gets us to a form that can actually be absorbed. So it turns out that absorbing hyaluronic acid is a bit like pulling apart a Lego structure. The digestive system breaks down the long chains of high molecular weight hyaluronic acid into smaller ones. It's just like how you might break down a Lego castle into the individual bricks before building something else. And these smaller pieces can then be absorbed and used by the body. However, even this process, the bioavailability of hyaluronic acid is very low. Just2% of the hyaluronic acid is actually absorbed. So there is still a bit of a puzzle. We do have some studies showing effectiveness, but it's very easy to have doubts because we do have evidence that so little of that hyaluronic acid is directly absorbed. So, it isn't exactly clear how it's driving these benefits. And as we've seen above, there are limitations with the existing human clinical trials, which is where this new

### [7:00](https://www.youtube.com/watch?v=ZZKdBM7D-3k&t=420s) New Clinical Trial on Hyaluronic Acid

study enters the picture. So, they set out to make a decisive new contribution to the literature. It's a double blind randomized clinical trial. It involved 150 participants and it used a broad set of objective measures of skin parameters and it lasted 12 weeks. And here we're getting data from a different population in central Europe. They analyzed the impact of hyaluronic acid supplements at two different doses and they looked at an impressive number of metrics. So they checked facial hydration, water loss through the skin, oil levels, elasticity, wrinkle depth, skin gloss, coloration, thickness, density, red patches, and pore size at baseline. and then again at every two weeks during the study. And the primary outcome was skin hydration on the cheek after three months of supplements. And the good news is that it was boosted by 11. 5% compared to the placebo in the group taking the higher dose of 120 mg per day of sodium hyaluronate. At the lower dose, the moisture increase was 9. 1% and the improvements showed up in other areas too. So there were significant reductions in water loss, oil production, and the depth of wrinkles around the eyes. They also found increases in skin thickness, density, and the presence of moisture boosting molecules in the upper layers of the skin. Coloration, pore size, and skin gloss though were not affected. So, a big takeaway from the study is that the results of earlier studies, they seem to be confirmed. Hyaluronic acid supplements drive measurable improvements in parameters of skin quality. But the study also gives us an insight into crucial questions around how hyaluronic acid is actually able to offer these improvements to the skin. It was this same team of researchers whose earlier 2023 study showed that at most there's about 2% of hyaluronic acid that's directly absorbed and makes it to

### [8:44](https://www.youtube.com/watch?v=ZZKdBM7D-3k&t=524s) Possible Mechanisms of Action

the skin. So the mechanism of action here appears to be indirect rather than direct. So how exactly does it work? What am I talking about here? So the authors propose three potential pathways of how hyaluronic acid supplements can offer these benefits. So one possibility is that hyaluronic acid supplements work by impacting the gut microbiome. So hyaluronic acid has been shown to promote the growth of bacteria that produce short- chain fatty acids and these fatty acids in turn can impact the skin through anti-inflammatory effects. They can promote healthy skin cell rejuvenation and enhance the skin's barrier function. A second possibility is that hyaluronic acid or components bind to receptors in the gut that help to promote systemic anti-inflammatory effects. And the third proposed way that it may work is that experiments with mice have shown that hyaluronic acid supplements can turn up the production of collagen and hyaluronic acid in the skin. But again, we are still quite uncertain about the exact mechanism of action for how hyaluronic acid supplements are offering these benefits. And it does seem like it may be acting through multiple different pathways.

### [9:46](https://www.youtube.com/watch?v=ZZKdBM7D-3k&t=586s) Key Takeaways

Now, some important caveats. The research here was funded by a company that makes hyaluronic acid supplements and several authors are employees. So that doesn't automatically mean that these findings are suspect, but it is something to keep in mind. Also, the absolute effect sizes with hyaluronic acid, they're relatively modest, and that's what we should expect from a supplement like this. It's only ever going to be one part of a more comprehensive approach to skin health. And questions do remain about the ideal dosing as well as the long-term benefits. For now though, hyaluronic acid does have an excellent safety profile and there is encouraging human randomized clinical trial data showing benefits for our skin, which is why I include it in microvitamin and microvitamin plus powder. There is something worth noting here though. The evidence that we have at this point suggests that there's no additional benefit with the expensive high molecular weight hyaluronic acid. It just gets broken down anyway and the effects that it produces are indirect as we've seen. So, I use low molecular weight sodium hyaluronate in microvitamin and microvitamin plus powder. But just because I take a supplement does not in any way mean that you should as well. And as I mentioned a moment ago, oral supplements like hyaluronic acid, they're just one tool among many when it comes to maintaining healthy, youthful skin. So, another one that's gaining popularity that sounds a bit counterintuitive is micro needling. So, just like the name suggests, it literally involves sticking small needles into your skin. So, does it actually help? Well, make sure to check out this next video here to find out what the latest data tells

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*Источник: https://ekstraktznaniy.ru/video/20560*