I Gave Claude Code My Whole Genome (And It's Amazing)

which sorts of exercise to do, and more. This totally changed my life. I found that I was a carrier for a debilitating disease called cystic fibrosis. I found what foods and vitamins work for me really, really well and which ones don't. And in general, I customized my health using my genetic data. Since then, my sleep has been basically perfect every night. I've had significantly more energy. I'm in the best shape of my life. And the best part is all of this used to cost tens of thousands of dollars just a few years ago. Now, it's accessible to everybody through Claude Code and a couple of clever workarounds. So, in this video, I'm going to go first over the results, including an actionable plan, a disease risk summary, and more, aka what you get from using a system like this. Then I'm going to show you guys how it works, including how DNA functions, which databases to use, and so on and so forth. Then finally, I'll cover some ways that you can do it, too. I'm going

to give you all the templates and all the files that you need in order to do this um down below in the description. And then I'll also talk about some ways you can extend this further into maybe a product or a health suite, how you can do this for maybe like your parents or your family members, and a couple of other things as well, just so we're all on the same page here. People aren't the same out of the box, right? We're different heights. We have different eye colors. We have different skin types and so on and so forth. The reason why is DNA. Essentially an instruction manual for how you are to be put together. It's the same thing as like architectural blueprints for a building. And the thing is all of ours are a little bit different. Now, in case you didn't know, your DNA is written as basically an alphabet of four characters, A, T, C, and G. And this is something of what it looks like. Obviously, this is a representation of your DNA. It's not going to be as beautiful and colorful and stuff like that zoomed in, but essentially we have these two double helyses over here. Okay? And both of them have these four letters attached. Cytosine, guanine, adanine, and thamine. Now, your DNA is really, really long. On average, it's something like 3 billion of these letters, which tell your body how to build and run everything that it needs to do. And the crazy thing is, and the whole reason why this works is because with today's science and access to consumer technology, you can actually export your entire DNA into a text file. Now, some of these text snippets are going to lead to good outcomes like maybe disease risk prevention, intelligence, and so on and so forth, whereas others are going to lead to poor outcomes. Think short lifespan, maybe skin damage, maybe prevalence of some risk of cardiovascular disease. What's really cool is by this point we've done a lot of studies on all the different snippets and what they ultimately result in terms of your health. So there are publicly available databases out there that catalog what all these different snippets of letters do. With Cloud Code, we can take that big text file because it is a large language model that does really well on language and then build a flow that takes this then consults these databases on your own snippets, interprets them using AI's natural intelligence and then gives you know a high quality report. It's worth me saying this obviously used to be really expensive. You needed genetic health consultations. You needed tons of tests and so on and so forth. But now anybody can have a personalized genetic report to allow you to customize how you treat yourself, your health, the foods you ingest, and so on and so forth for a fraction of the price. And

fraction of a fraction of the price. And I'm going to show you how to do all that in a second. So the system itself is right over here. Now I visualize this using a tool called Excal. And I'll run you through how all of it works in a second. But first, I just want to show you the cloud code workspace and then make sure that we're all on the same page regarding the files and uh cloud. mds and so on and so forth. So this is my cloud. md. And for anybody that doesn't know, this is the highle instruction that is injected at the beginning of every conversation inside of my IDE uh in this case VS Code. What this is a comprehensive genetic health analysis pipeline that processes data from a particular provider called 23 and me to generate detailed health reports. It's worth noting that I got my DNA tested for like 70 or 80 Canadian dollars. Granted, this is a few years ago, but all different services have uh nowadays, most of them anyway, have the ability to export your genetic data as a giant text file. And when I say giant text file, by the way, this is what I'm referring to. I mean, we could take this and scroll all the way down here to like 600,000 lines, and we're still getting little snippets of uh DNA. So, I'll give you guys a list of different providers you could use for different areas around the world and so forth at the end of this, but at the, you know, to make a long story short, they basically mail you a tube. You spit in the tube, you mail it back, and then a few weeks later you get your DNA. So the output of this claw. mmd is three reports in the reports directory. We have first an exhaustive genetic report. Now this gives us an analysis of our lifestyle and our health genetics including drug metabolism, which is really important, methylation, which in my case I had a particular issue with, nutrition, your fitness, your cardiovascular health, your sleep and circadian rhythm, and then also some drug gene interactions from a database called farm key uh GKB. And so essentially some people here just do worse with specific drugs because of the way that your DNA is written. After that we get an exhaustive disease risk report including a pathogenic variants. So if you have you know cystic fibrosis carrier gene like I do for instance is where you'd figure that out. Your status for recessive conditions, risk factors, drug response variants and then protective variants. And then finally an actionable health protocol which is a comprehensive protocol that basically summarizes all this and then gives you like a daily routine to use. And since using this daily routine, I've maxed out my sleep score. I've been recovering significantly better in the gym. I've been in the best shape of my life, and I've hit PRs that I never really thought I'd be able to do. You also get a bunch of other stuff like dietary frameworks, exercise protocols, blood pressure management, and so on and so on and so forth. If you're interested in optimizing your health, though, that's the one that you want to spend most of your time on. So, I'm not going to go through the rest of this claw. md because that's more or less the most important part. Um but there are different impact magnitudes which are basically the scientific consensus on how likely a specific uh what are called single nucleotide polymorphism S& P or little gene snippet to causing an impact on you and your DNA. And so there's an impact magnitude scale here between 0 to six where if it's a zero you probably don't need to take it super seriously. If it's a one there's probably a minor effect. If it's a two it's moderate three high. And if it's between a four to a six, you should absolutely take a look at it because there's just a wealth of knowledge out there on a specific um you know gene effect. And in all likelihood, you're probably suffering from it in one

way or another. The last thing I'll say before I run this puppy is I'm not a doctor. This is not meant to, you know, replace actual medical professional on any of this stuff. Obviously, we're doing what we can with what we have. Not everybody here has access to super straightforward, easy healthcare, and this is not a substitute for that. But it is a way that you could take maybe a little bit more of your health into your own hands. If you're the sort of person that freaks the hell out about this stuff, if you're the sort of person that would read, you know, your genetic data and then see some disease risk or something and not be able to sleep for the next year, I don't necessarily recommend going through this. But if you're the sort of person that can look into the void and, you know, confront it and be okay with it and use it to improve your life, then I certainly think this has tremendous value for you. Okay, so like with any agentic workflow or IDE or cloud codebased thing, obviously it's a chat box, so I'm going to talk to it. And uh in my case, I already have a couple of reports that I previously generated, including the actionable health protocol, complete health report, the risk report, genetic report, and just a bunch of other subsidiary things. Like I ask it to generate me a meal plan, a shopping list, a list of supplements, and so on and so forth. But just because of that, I'm going to have it generate a new one, and I'm going to be very explicit in it. I'd like you to generate a new set of health reports. I'm doing this for a demo, so it's important that you go through the entire process start to finish. Um, call them all V2 at the end of it. Don't just duplicate my prior reports. Once I press enter, it'll start working. So, we go to thinking and it's going to run the full genetic health analysis pipeline for me. It does so pretty quickly because we've basically gone out and already gotten that data from the databases. You can see that we now have the full genetic analysis and it's generated a bunch more reports. It processed 621,000 single nucleotide polymorphisms and scanned against a bunch of ClinVar entries and, you know, a bunch of other databases and stuff like that. So, what is the what do these things actually look like? Now, I'm going to use the actionable health protocol because that's just the most interpretable for you guys, and I'll let you guys take a look at the other ones. I don't want this video to be three hours, but uh at the very top, you're going to get something like critical genetic findings. It's going to tell you about things that it considers to be highly relevant to you, things you should probably get checked out. So, in this case, it recommends I get an echo cardiogram, for instance, because I have uh some form of, and you know, it's a low confidence, mind you. It's not telling me you need to do this right now. Holy crap, you're going to die. But it says, hey, genetically speaking, you may have congenital heart disease. You may have some manosbinding protein deficiency. you're a cystic fibrosis carrier with high confidence. You have these uh pathogenic uh you know variance and so on and so forth. And not a lot of this stuff is super relevant to me. But if I continue scrolling down, you see that it gets a lot more specific about what I should do. So for instance, you're a confirmed carrier of this disease. Health implications. You have 10% reduced lung functions. You have 2 to 3x increased risk of pancreatitis. You have a higher prevalence of chronic rhinocitis. I don't know what that is. And possible male fertility effects. So in my case, you know, I should probably do a baseline pulmonary function test. I should probably not smoke, a recommend genetic counseling because if I have a partner uh and they have the same thing, then our kids's probably going to have this terrible disease and so on and so forth. Underneath that, I have a daily protocol which recommends various supplements to take to basically balance out my body's inability to produce a variety of nutrients and chemicals. So for instance here it recommends that I supplement with this thing called methylolate which in my case one of the pathways that's used to generate some energy and so I need to supplement with this thing called methylolate right over here to kind of make up for it. Um this is probably the biggest lifestyle improvement I noticed almost immediately within 2 or 3 days after taking this consistently. Uh my energy levels are through the roof and my sleep significantly improved. But there are variety of other recommendations as well. I should take pre-formed vitamin A, lutein and zeazanthin and vitamin D3 and so on. Now, I don't recommend just taking a big supplement stack at once. I recommend kind of introducing it into your lifestyle slowly but surely. This is the first thing that I introduced. I felt an impact. So, then I continued down the way. I found that some of these things kind of upset my stomach and stuff like that. So, I'm still in the process of figuring out exactly what timing to take these and so on and so forth. In my case, I'm a very poor metabizer of caffeine. And so despite the fact that I used to love drinking, you know, a big Starbucks of menty frappa mocha latte with three extra cherries on top or whatever, uh, you know, I found that it just has absolutely bodied my my sleep, my energy levels, maybe really anxious and stuff like that. So it actually tells me, hey, you should probably wait for your adenazine to clear 90 to 120 minutes. When you take a coffee, you should probably take much less of a coffee than you would imagine. You're an intermediate metabolizer. You have slow dopamine clearance and so on and so forth. None of these are like self-fulfilling prophecies, right? And I don't want anybody here to like read one of these and get really freaked the hell out about it, but suffice to say, tremendous amount of value. Notice how it gives you midday supplement recommendations, evening supplement recommendations. I have a big dietary framework here that it recommends for my own longevity, uh, loading potassium, and yeah, I can go really, really deep into this stuff, but essentially, ever since incorporating all of these actionables into my day-to-day life, I felt substantially better. And, uh, you know, this is something that previously would have cost me5 $10,000 to do. I'm going to give you guys access to all this stuff.

Obviously, not my own actionable health protocols and analysis results, but everything else that you guys need. Um, but what's cool is once you have this, you could very quickly and easily just ask Claude Code to come up with some other things for you. So, for instance, I had to come up with a little meal plan here. And I've actually eaten a fair few of these at this point, which is quite nice. I told her that I was, you know, aiming to bulk up and, you know, I'm at the gym. I need certain protein uh goals and stuff like that. And I went through and it just gave me a bunch of breakfast options. um simple and straightforward lunch options, you know, dinner options, so on and so forth. Something else that was super cool to me was genetic optimized shopping list where it basically ran through and gave me a bunch of things that, you know, I could buy uh that automatically give me a lot of the nutrients that, you know, my body is asking for. So, I'm not going to eat all these things. For instance, I absolutely hate tempeh to death and uh that's definitely not making it onto my shopping list. But, you know, just being able to communicate with it on essentially a knowledge base that is you is super valuable as I'm sure you can tell. So, with all that done, let me run you through at a high level how all of this works. Basically, what you do at the beginning is you feed in that big text file, which in my case is just genome. txt. It has a script called run full analysis. What this full analysis does is it takes your big genome, which is separated into a particular format depending on what provider you use. In my case, I use 23 and me. It verifies whether it's valid and if so okay it calls two major databases. The first is farm GKB and as you see here it's a comprehensive clinical pharmaccogenetic resource created to support and expand knowledge on pharmaccogenetics which is essentially the interactions of various pharmaceuticals with your own genes. Some people are much more likely to be sensitive to things like caffeine. Some people will take certain antibiotics and it'll really screw them up. other people will take various drugs, steroids, whatever the hell you're doing and uh because of your pre-existing genetic factors that'll work either better for you or worse. And so this is the first thing that I was really interested in figuring out. Simultaneously with that, it also calls ClinVar, which is a database that essentially aggregates tons of information about all of the various variations in your genetic code. And then contrast that against published studies that are out there, saying, "Hey, we ran a big study on 10,000 people and we found that when they had this genetic variant, it led to significantly higher likelihood of this. " Or when they had this genetic variant, it meant that they were better at sprinting or whatever. There are a couple of other smaller databases out there that provide less information than both of these, but basically the very first thing that the script does is it just gets all of the information related to the snippets of your genome that you have fed in. From there on the left hand side, it'll match your pharmaccogenomics and it'll identify drug interactions before giving you some sort of aggregated result. In the middle here, it'll run a full health analysis matching what are called single nucleotide polymorphisms as little changes in your genes to the database. Then it'll categorize them as drug metabolism, methylation, nutrition, fitness, cardiovascular, sleep. And on the right hand side with all these disease from ClinVar will identify if it's like a true SNP. Sometimes it's not. And then it'll classify the significance in four bins. Pathogenetic variance, carrier status, risk factors, and protective variance. What's really cool here is like there are a few services out there that already do this sort of thing. Basically, they allow you to, you know, uh, pump in your genome or whatnot, and then they cross reference it against a bunch of things, and they spit out some really dry summary, but these are really dry summaries. You can't really do much with that. And to be honest, like, unless you have a bunch of genetic knowledge, unless you're basically like a freaking full-blown doctor, your ability to interpret this stuff will be very, very minimal. And so, what this does is it allows you to basically take all of this and almost like how you can upload a PDF to ChatgBT and talk back and forth with it, you can do the same thing here. You can basically talk back and forth with your own genome. After that, we generate three reports. We have the actual health protocol, the exhaustive disease risk, and then finally the exhaustive genetic

report. Okay, so if you actually wanted to do this yourself, how would I go about it? Well, the very first thing you're going to need to do is go and find some way to obviously sequence portions of your genome. So, there are five main services right now that I'd recommend if I remember how to draw on an uh the first is 23 in me. The second is ancestry. The fir the third is uh I think it's called my heritage. The fourth is I think living DNA and then the fifth is I think it's called family tree. And you'll see that a lot of these are focused around the family component, right? Ancestry, your heritage and so on and so forth. And the whole idea is like basically instead of doing all this science stuff to find out um gene snippets for your own health. They just show you which people have had this test that are similar that you might be related to based off genetic proximity. What's cool is a lot of these allow you to export your raw genome. And so you could use these in order to basically, you know, get a test kit between $50 to $100, spit in a tube, and then when you send it back in a few weeks, as mentioned, they will give you your raw genome. So in my case, I use 23 and me. 23 andMe has a particular format that uh they force the output to be, which is a little bit different from the ancestry, heritage, uh family tree ones, and so on and so forth. But, you know, all you really need to do if you're using a different provider is when you get the results back, just upload it as genome. txt txt and just say, hey, instead of the 23 andme format, I'm using the ancestry DNA format or something like that. And by doing so, it'll have, you know, publicly available information what that format looks like and it'll just change that into one that works for the API calls um in our system. Now, I should note that there is a technical difference here between what we're doing and then like a full DNA test. Um, what these are called are genotyping. Now, genotyping is basically where you look specifically for around 600,000 or so gene snippets cuz like you do have a very long DNA snippet, right? Uh we talked about 3 billion letters. So, instead of the 3 billion, we just look at like the 600,000 that are the the most likely to have impacts and stuff like that on health, the ones that are most studied. But you can also do what's called full genome sequencing if you wanted to go a little bit further, which allows you to read through all 3 billion of those. And the resulting text file is freaking massive, by the way. Um, you'll get more data with full genome sequencing, but I want you to know that it's like a marginal improvement. I think you probably get 80% of all the information that you need in order to make actionable health decisions from genotyping. And it only costs, as mentioned, like 50 to 100 bucks usually. Um, you know, the full genome sequencing will certainly squeeze out a little bit more of that, but you know, in this case, uh, we get to the point where it's like, I don't know, $300 to maybe like $500, which I think makes it less accessible for the average consumer. And

if you wanted to do this for yourself, all you'd really have to do is click on the link in the description. You'll open up the claude code has my genome appropriately named uh folder here. You'll find a genetic health folder. What you do is just rightclick, download that. You guys will get that in the bottom right hand corner as a zip file. From there, what you need to do is open up any IDE or integrated development environment. Uh I'm going to be using VS Code for this. Then inside of VS Code, I'll go open folder. I'll just go to downloads. See if I could find a genetic health. There we go. And then just click open. Now you'll have loaded up all of the context and files and stuff like that I had there on that demo that I showed you. There'll be nothing in tmp. It's just a temporary folder inside of data. You'll have all the information from these various services and databases. So clinvar farm c uh gkb and so on and so forth. There'll be nothing in reports. That's where all of yours are going to go. And then finally underneath scripts you're going to have things like the analyze genome full health analysis and stuff with cloud. mmd. Once you're done with that all you do is you go and you upload your genome. So, I'm going to go find it. In my case, mine's right over here. I'm going to go drop it into data. Now that I have this, I'm going to go open it up in Cloud Code. So, just double tap anywhere in the screen. Click on that little puppy. [sighs and gasps] I'll go over here and I'll say, "Hey, could you run a genetic analysis on genome. txt and it'll have all the contacts of what it needs to do with cloudmd. Sometimes it forgets which Python instance to use, and that's fine. There it goes again with the damn Python 3. It's my own fault. " uh it'll go run the full genetic analysis based off of your genome and then boom, you have those three files that I showed you guys earlier. So you have actionable health, disease risk, and then genetic report as well. Click on whichever ones you want, and then boom, now you have it. You could also get, you know, your parents DNA, help them out if they wanted to know that. Maybe you have a friend or a family that's wondering if they have some genetic condition or whatever. I don't recommend just like being like, "Hey, let me do this for you. " I do recommend asking them and saying, "Hey, you know, are you comfortable with this? Do you want me to run it for you? Do you want yourself? Maybe link them this video or something. Um, also make sure they understand that by doing this they will reveal a fair amount of information about themselves. And I think for some people that's fine as mentioned, but for other people I can really freak them out. I'm reminded of an instance in which somebody reasonably close to me did some um big full body MRI and then they found out that they have some little brain thing which might pop at any moment and kill them. And they freaked the hell out about it for a couple years or something like that, thinking about it basically every night before they did uh, you know, another test and they found out that it was just a false positive. And so there is, you know, some false positives here. Obviously, treat everything I'm saying with a grain of salt, but the ultimate goal is just to empower your health and become better at uh managing your own life. Now, in terms of ways that, you know, you can expand this and keep on going. Um, I was thinking about ways to do so. Obviously, the first is you could take everything that I've shown you here and then do a full genome sequence and then maybe you could squeeze another 20% of it out of there. You could also use this to build out say like a product suite where you know uh you take somebody's uploaded genome and then you use AI to explain in simple and natural language like the things that the person needs to do in order to you know probably have a better life. You could build probably like a little iOS app. You could probably build a little Android app to do that if you really wanted to. You could also contact these major companies and maybe build something out that works in tandem with them. For instance, I think that it is a real tragedy and shame that 23 andMe and Ancestry and these other services don't just provide what I'm showing you right out of the box because I think it's like so extraordinarily powerful and helpful for a lot of people. You could take these summaries, give them to people like your personal trainers at the gym. You could give them to, I don't know, your doctor, for instance. You could build brief little summaries here so that your doctor has all the context that they need on uh things that you are genetically predisposed to. Obviously, don't freak anybody out and some doctors really hate it when you try and advocate for your own health like that. So be

careful. But um suffice to say, all of this stuff will just help empower you a little bit more. Before you have kids, I would highly recommend doing something like this. Um genetic counseling and whatnot can be pretty expensive depending on where you are in the world. Uh whether or not you know your healthcare is public or private or whatnot. So uh I would recommend doing something like this. In my case specifically, as mentioned, I'm the carrier of a pretty debilitating disease, cystic fibrosis. There's some mild impacts on my health and stuff like that as a result, but the main thing is uh mostly like my kids. So before I have children um you know I'm going to make sure that the person that I'm going to have children with does something like this so we could see hey you know do you also carry this gene which only has you know 3 to 4% incidence rate in my population. If so we're going to have to talk about how to approach this a little bit differently. So yeah all of it for the benefit of you health your family and so on and so forth. And I'm really excited to be able to share stuff like this with you because I think that's really the next step of not just cloud code for building apps and stuff like that but also for things like your own

healthcare. So, if you do anything cool with this, if you end up building a cool product or, I don't know, just running it on yourself and figuring out something cool, let me know. I would absolutely love to hear. Um, one thing I didn't mention here at all were any of the privacy concerns involved in uploading your DNA to a service. I want to make it clear here that I don't care about that personally. A lot of people here might. So, if you've been hearing alarm bells the whole video, that's okay. Sure, send me a comment down below. You know, we can chat about your own personal thoughts on that and, you know, whether it's okay that big LLM owns your whole genome. But, uh, my take on it is like they already own basically everything about you, so it's not that big of a deal. Uh, if you guys want to build this sort of thing yourself, but you're not entirely sure how to do so, leave a comment down below. More than happy to help you. I'll walk you guys through maybe some additions to the system and so on and so forth. And if you guys like this sort of thing, do me a solid, subscribe to the channel. A big chunk of people that are watching are unfortunately just not subscribed for whatever reason. That's just how YouTube is. Hopefully, I helped you with something cool today. Have a lovely rest of the day and I'll catch all you'all in the next video. Thanks so much. bye.