Deep Learning and Cancer Research | Two Minute Papers #64

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Deep Learning and Cancer Research | Two Minute Papers #64

Two Minute Papers 08.05.2016 9 974 просмотров 255 лайков

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A few quite exciting applications of deep learning in cancer research have appeared recently. This new algorithm can recognize cancer cells by looking at blood samples without introducing any intrusive chemicals in the process. Amazing results ahead. :) _________________________ The paper "Deep Learning in Label-free Cell Classification" is available here: http://www.nature.com/articles/srep21471 The link from Healthline: http://www.healthline.com/health/cancer/ovarian-cancer-facts-statistics-infographic#10 Recommended for you: Two+ Minute Papers - Overfitting and Regularization For Deep Learning - https://www.youtube.com/watch?v=6aF9sJrzxaM WE WOULD LIKE TO THANK OUR GENEROUS SUPPORTERS WHO MAKE TWO MINUTE PAPERS POSSIBLE: Sunil Kim, Vinay S. https://www.patreon.com/TwoMinutePapers Subscribe if you would like to see more of these! - http://www.youtube.com/subscription_center?add_user=keeroyz The thumbnail image background was created by zhouxuan12345678 (CC BY-SA 2.0). Some blood cells were removed. - https://flic.kr/p/9ATvC1 Splash screen/thumbnail design: Felícia Fehér - http://felicia.hu Károly Zsolnai-Fehér's links: Facebook → https://www.facebook.com/TwoMinutePapers/ Twitter → https://twitter.com/karoly_zsolnai Web → https://cg.tuwien.ac.at/~zsolnai/

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Intro

Dear Fellow Scholars, this is Two Minute Papers with Károly Zsolnai-Fehér. Let's try to assess the workflow of this piece of work in the shortest possible form. The input is images of cells, and the output of the algorithm is a decision that tells us which one of these are cancer cells. As the pipeline of the entire experiment is quite elaborate, we'll confine ourselves to discuss the deep learning-related step at the very end. Techniques prior to this one involved adding chemicals to blood samples. The problem is that these techniques were not so reliable, and that they also destroyed the cells, so it was not possible to check the samples later. As the title of the paper says, it is a label-free technique, therefore it can recognize cancer cells without any intrusive changes to the samples. The analysis happens by simply looking at them. To even have a chance at saying anything about these cells, domain experts have designed a number of features that help us making an educated decision. For instance, they like

Features

to look at refractive indices, that tell us how much light slows down when passing through cells. Light absorption and scattering properties are also recognized by the algorithm. Morphological features are also quite important as they describe the shape of the cells and they are among the most useful features for the detection procedure. So, the input is an image, then come the high level features, and the neural networks help locating the cancer cells by learning the relation of exactly what values for these high-level features lead to cancer cells. The proposed technique is significantly more accurate and consistent in the detection than

Importance

previous techniques. It is of utmost importance that we are able to do something like this on a mass scale because the probability of curing cancer depends greatly on which phase we can identify it. One of the most important factors is early detection and this is exactly how deep learning can aid us. To demonstrate how important early detection is, have a look

Survival Rates

at this chart of the ovarian cancer survival rates as a function of how early the detection takes place. I think the numbers speak for themselves, but let's bluntly state the obvious: it goes from almost surely surviving to almost surely dying. By the way, they were using L2 regularization to prevent overfitting in the network. We have talked about what each of these terms mean in a previous episode, I've put a link for that in the description box.

Head Tip

95% success rate with the throughput of millions of cells per second. Wow, bravo. A real, Two Minute Papers style hat tip to the authors of the paper. It is really amazing to see different people from so many areas working together to defeat this terrible disease. Engineers create instruments to be able to analyze blood samples, doctors

Outro

choose the most important features, and computer scientists try to find out the relation between the features and illnesses. Great strides have been made in the last few years, and I am super happy to see that even if you're not a doctor and you haven't studied medicine, you can still help in this process. That's quite amazing. A big shoutout to Kram who has been watching Two Minute Papers since the very first episodes and his presence has always been ample with insightful comments. Thanks for being around! And also, thanks for watching, and for your generous support, and I'll see you next time!

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