What 10+ Human Trials Reveal About Berberine

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What 10+ Human Trials Reveal About Berberine

High Intensity Health 04.01.2026 65 018 просмотров 2 834 лайков

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Berberine is a natural plant compound with a long history of human clinical research supporting its role in metabolic health and appetite suppression. Support your Intermittent Fasting lifestyle with the Berberine Fasting Accelerator by MYOXCIENCE: https://bit.ly/berberine-fasting-accelerator Use code podcast to save 12% Get the Blood Work Cheat Sheet: https://courses.highintensityhealth.com/blood-work-cheat-sheet -------------Health and Sleep Tools!----------------------- The Best Micronized Creatine: https://amzn.to/3HTufYu Berberine Fasting Accelerator: https://amzn.to/3NWv97i Eat like your life depends it Tee Shirt!: https://bit.ly/3dEHM3e Best Sauna Blanket: https://bit.ly/best-sauna-blanket Best Mouth Tape (Nexcare): https://amzn.to/31qJayh Get this Metabolic Book: https://amzn.to/3pEfvmZ NeilMed Nasal Wash Kit https://amzn.to/3EUQaY Breath Right Strips: https://amzn.to/31t5VSl A Metabolism Book Should Have:https://amzn.to/2jUiAh5 -----------------------------------------Show Notes-------------------------------------- 0:00 – Intro 0:53 – Source & quality issues: synthetic vs wildcrafted berberine 1:54 – Why berberine works: gut microbiome & incretin hormones 2:46 – HIMABERB® sourcing & pleiotropic effects 3:37 – Natural compounds vs pharmaceuticals (statins, SSRIs) 4:36 – Dihydroberberine vs berberine HCL (lack of human data) 5:28 – Why absorption isn’t always the goal (gut-mediated effects) 6:26 – Human trials: triglycerides, cholesterol & lipid markers 7:35 – Blood pressure reductions in clinical studies 8:48 – Glycemic control, fatty liver & liver enzyme improvements 9:43 – Berberine & cancer research (human clinical data) 10:42 – Drug–drug interactions & safety considerations 11:46 – Bioavailability myths & gut mechanisms explained 13:02 – Review conclusions: cardiovascular & metabolic benefits 13:48 – Practical dosing, appetite suppression & real-world use 14:30 – Final thoughts & viewer takeaway

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Intro

In today's video, let's review the data about a tool that can support your metabolic health. This tool is known as bourberine hydrochloride. It actually has a large and long dossier of human clinical research and we're going to review that right now. This was one of the most I think detailed reviews about how bourberine can improve various aspects of metabolic health from fatty liver disease to polycystic ovarian syndrome to dislycemia, poor blood sugar handling and beyond. Uh this was an excellent recently published summary of all of the human clinical data. They do include some of the animal model data which I'm going to completely ignore because I don't want to recommend something that just says animal model studies. I want to uh focus on what is bourberine hydrochloride. So this is actually derived from the berberous aristata plant. And this is something you should really know about. There's a lot of synthetic bourberines on the marketplace uh that are made from prochemicals. uh a lot of the uh Chinese

Source & quality issues: synthetic vs wildcrafted berberine

source material is has been uh tested via carbon 14 data and it's not burberous aristata. It's not derived from wildcrafted bourberine found in the Himalayas. So there's only one company that's doing that. I'll share with you momentarily about that. But bourberine is a polyphenolic structural compound and it's actually really poorly absorbed and that's the magic of bourberine. seems to impact both diversity of the microbiota, the gut bacteria that reside in your small and large intestine and it also improves the release of incretin or gut hormones and these have been recently popularized with the uh push for semiglutide and ompc and so forth all the so-called increin hormones. Uh these are peptides that your gut makes when you start eating food. But as you get more metabolically unhealthy, you start to gain more body fat. your small intestine starts to release less of these hormones and therefore you have more post-meal processing disorders i. e. hyperinsulinemia, high triglycerides, high blood glucose, polycystic ovarian syndrome, fatty liver disease and so

Why berberine works: gut microbiome & incretin hormones

forth. And so um it turns out that bourberine is like nature's way of improving and optimizing these gut hormones. Now if we didn't have 93. 6% of us adults having some degree of metabolic dysfunction, we probably wouldn't need to recommend bourberine. You know, only one in 10 US adults has optimal metabolic health. Most people have some degree of poor metabolic health. And so what I like about bourberine is there's tons of data on this and you can actually feel and notice the results. The first time I started to use bourberine, not for metabolic health, but to increase my ketone levels, I noticed a significant drop in my blood sugar and a significant conccommittent rise in blood ketones because I was really into testing my ketones in 2015, 2016. started to think about this myioscience brand and what formulas we're going to come out with and I was like we have to find a really high quality bourberine and we did

HIMABERB® sourcing & pleiotropic effects

secure that from the Hima folks over in the Himalayas which I'll just put links in the description below. I'm not going to talk about the product. If you want to you know look at a carbon 14 verified wildcrafted handh harvested berous arristada pure bourberine hydrochloride product it'll be in the description below. That's where we're going to go here because we're going to talk about conditions that are actually very serious like aththeroscerosis and and other things. So, I just want to uh let you know that is an option here. But I want you to know that bourberine has pleotropic effects. And so, here's figure two, mechanisms related to how bourberine functions in the body. And this is largely derived from animal model studies and tissue culture studies. So, I'm not going to lean on this too much, but what I like about natural compounds and even metformin, it's derived from the French lilac, which is a plant. Natural

Natural compounds vs pharmaceuticals (statins, SSRIs)

compounds tend to have pleotropic effects. In contrast, pharmacologic compounds, you know, an SSRI, for example, other things that might lower your blood pressure, they're very specific to a one particular target or inhibiting an enzyme. If we think about statins now I know statins exist in nature and so forth from red yeast rice there's multiple statin compounds but it seems that bourberine has these pleotropic effects which is also exciting because most of these pleotropic effects are positive uh affecting mitochondrial function affecting glucose metabolism insulin response in hormone release and so forth. So here are all the mechanisms about how bourberine might affect metabolic health. So now I do want to talk about dihydroberourine. I'm not a big fan of this because bourberine has this inside out control. I know theoretically it's better absorbed but there is this level of there's not a lot of free bourberine in the blood after taking dihydroourberine. And as you will

Dihydroberberine vs berberine HCL (lack of human data)

see in this data set there is not a no human data up to now we're filming this in early November of 2025. No human data on dihydroberine. It's all on bourberine HCL. So why would we recommend a product that has literally no research on it because it's theoretically better absorbed. Imagine [snorts] if someone came to you and said, "Hey, you know, we know all the beneficial effects of metformin. " Well, what if we can get metformin better absorbed? Would you want that? I don't know. Would you would that mean that it it's it would have better clinical outcomes? I'm not so sure because we're ignoring the effect of these compounds and how they impact the gut bacteria and the gut hormones. So if we bypass all that, we might bypass some of the therapeutic benefits. So we don't always need to optimize absorption. You know, if we're talking about vitamin B12 or we're talking about creatine, creatine works within the muscles

Why absorption isn’t always the goal (gut-mediated effects)

right? We want creatine to be absorbed. If we want vitamin B12, it works in your liver and your brain and so forth. Um you supporting methylation, right? So you want that to get into your liver, right? Because that's where most methylation reactions occur. But in the context of bourberine and metformin, it seems that most of the mechanisms of action occur in the gut. So chasing absorption with liposomes and all this stuff uh doesn't make a whole lot of sense uh to me. So I I don't think that bourberine hydrochloride is all that exciting. Now let's look at the summary of human clinical trials based on their effect in the body lowering cholesterol in humans. So this is a summary of eight or more human clinical trials dating back to 2012 all the way up to 2022. So in 365 diabetic individuals, bourberine decreased uh total cholesterol and LDL cholesterol. Um I'm not so concerned about total cholesterol or LDL

Human trials: triglycerides, cholesterol & lipid markers

cholesterol. I'm actually more concerned uh about triglyceride reduction. I get more excited about this. So this was uh a 2016 study in individuals with mild hyper lipidmia. Just 300 mg of bourberine lowered triglycerides. Uh 1,200 milligs of bourberine in three divided doses also lowered triglycerides in women with PCOS and so forth. So low dose between 300 and 500 milligrams per day seems to affect blood lipids which I think is quite interesting. What about blood pressure? We're looking at table three here. So six clinical trials or studies uh that have looked at how bourberine affects blood pressure in individuals who have hypertension uh you see significant shifts in both systolic and diastolic blood pressure at low dosages ring ranging from 300 milligs up to 500 milligrams three times a day. So most studies for bourberine vary from 500 milligrams up to 1500 milligrams per day. Most people do not need more than that. All of these six studies show that bourberine lowers blood pressure. So we have a lowering of

Blood pressure reductions in clinical studies

triglycerides as I mentioned eight studies there. Uh six studies finding lowering of blood pressure. Now what's interesting is we have animal model studies on glycemic parameters and then we have human studies. We have 1 2 3 4. We have over 10 human studies finding that bourberine improves blood sugar metabolism in humans. Decreasing fasting glucose, decreasing 2-hour oral glucose tolerance, decreasing hemoglobin A1C fasting glucose as well as liver fat in women with PCOS and naf non-alcoholic fatty liver disease. So really good data to show in humans these studies are not super old. Some are really new. uh several in 2021, several in 2020 and 2023. Uh the earliest study that was cited here in the summary was 20 uh 10. Okay. What about fatty liver disease? We have more than six studies finding that bourberine helps improve lipid profiles andor liver enzymes and also ultrasound studies that show that bourberine reduces liver fat content as well as your three liver function tests. So, if

Glycemic control, fatty liver & liver enzyme improvements

you downloaded our blood work cheat sheet over at highintensityalth. com, you know this. You have your ALT, A, and GGT. Uh, studies show that when those liver function tests go over 30 units per liter, that's problematic for, you know, the future and prognosis of your liver as well as cardiovascular health. Bourberine improves liver enzymes by supporting metabolic health. So, I think that's important. All these uh studies show and some use ultrasound, some use MRI and so forth. And these are not small studies. 180 individuals with fatty liver disease, 68 disease. So decent number of subjects in these studies find bourberine at higher dosages here. Some of these studies lasted as long as 16 weeks or 18 weeks, one or two grams per day. The highest dose was six grams per day. I wouldn't recommend that. That would probably cause some gastrointestinal distress in people. So

Berberine & cancer research (human clinical data)

I think less is more for most folks honestly when it comes to bourberine. Now let's talk about bourberine and cancer. This is really interesting. We have five clinical studies in individuals with colurectal cancer uh cervical cancer and other types of cancer finding that low doses of bourberine 300 milligs to 600 milligs per day uh actually had a decreased recurrence rate of colurectal adinomas. And also they looked at lymphas and cervical cancer improvements in those different uh affformentioned cancers. So again this is a natural product a natural compound and it kind of makes sense that bourberine might improve the prognosis of someone diagnosed with cancer because we know that metabolic health and cancer are intimately connected and impossible to disentangle. So uh that to me makes a lot of sense. I think this is um important. Now what about the risks uh particularly the drug interactions with bourberine I think this is important there might be

Drug–drug interactions & safety considerations

effects um linked with uh tmoxifen so for individuals who are on novidex for say breast cancer or something uh cypro there tends to be uh a potential for antibiotic dose reduction so if you're taking cypro for an infection um [snorts] metformin there seems to be conflicting effects with metformin cycllosporin warrin uh and possibly kakconazol. So those are things that people should consider. We're talking about table 8 here uh as well. So here's the thing I think is important for folks to understand is that bourberine is well known to have low intestinal absorption and poor bioavailability, but obviously it has clinical effects. And so how does it work? It works within the gut, improving diversity, improving the gut hormones and so forth. So, I think that's something that we should definitely uh consider and it might even improve the uh intestinal tight junctions and help with intestinal permeability. So, I think that's something that should be considered. But

Bioavailability myths & gut mechanisms explained

overall, in this review, the investigators say bourberine shows a promise for low toxicity and is a potential therapeutic agent for improving carvascular health by enhancing lipid profiles, reducing inflammation, and promoting endothelial function despite bioavailability challenges. Again, when it comes to these herbs, we don't always want to optimize bioavailability because most of these herbs actually work in the gut. So, I think that's important. Its therapeutic effects on atherosclerosis and ashimic heart disease lipid profiles, lowering blood pressure, and enhancing glycemic control offer a promising alternative to conventional treatments with fewer side effects. Highlighting the value of incorporating natural supplements like bourberine into lifestyle changes for better health outcomes and chronic conditions. Its multiaceted effects make it a valuable adjunct in managing non-alcoholic fatty liver disease, especially amid rising obesity and type 2 diabetes. They even go on to say the research underscores the promising role of bourberine as a potential anti-cancer agent revealing its capabilities in modulating a range of cellular mechanisms critical to tumor growth and metastasis. Brain has been shown to influence various pathways involved in cell proliferation, apoptosis and angioenesis which are fundamental processes in cancer development and progression. So I think this uh you know

Review conclusions: cardiovascular & metabolic benefits

suggests that there are promising findings with regards to bourberine as a natural compound that can help support metabolic health. I would encourage you to try this you most studies find and advise people to take bourberine 30 minutes before major meals. So this could be lunchtime, this could be dinner time. Starting on the low end of 300 millig up to say 750 millig once or twice per day. I found anecdotally this works as a natural appetite suppressant. So this can be effective this time of year around the holiday seasons. You, you know, when you go to these dinner parties and holiday parties when there's more food availability, you tend to eat more. And if you're prone to trying and sampling everything, you know, you have 2,000 calories, you know, you're like, I didn't exercise today. That can be a problem. And that over time can lead to weight gain. So, if you're like me and

Practical dosing, appetite suppression & real-world use

you like to taste everything and overeat when you're in a big group, you might want to try bourberine. I would just take 500 to 750 milligrams before you go to a party and see what you might notice with regards to your cravings. I found it helps with alcohol cravings as well as food cravings. So, I would like to know what your thoughts are. Let me know in the comments section below for products and reviews. I'll put those in the description below. And I'll also put this article in the description below as well. I'm grateful that you tuned in to the very end.

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