Retatrutide is Changing Fat-Loss in 2026 (Beginners Guide)

Retatrutide is Changing Fat-Loss in 2026 (Beginners Guide)

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Segment 1 (00:00 - 05:00)

Rea True Tide's phase 3 trial results just dropped. And after actually reading the data myself, I'm not surprised at all because for the last 10 weeks, I've been personally experimenting with Rea. And I can tell you right now, this is not just a fat loss drug. This is not ompic with better marketing. This is definitely not something you can understand through Instagram clips if you never used it before. As someone who spent years abusing fat burners and stimulants and steroids, Red True Tide is a completely different animal. So, in this video, I'm going to break down the phase 3 data and what actually it showed because there's parts of this that people are ignoring and why this drug actually behaves differently than semiglutide and draptid. And then I'm going to walk you through my personal 10e protocol. I'm going to talk you about the dosing, the timing, how I stacked with the other peptides and how I got back down to roughly 8% body fat without wrecking my body and losing my muscle. Let's get into it. Roide is a tripal agonist compound, right? So, it targets three things. GLP-1, GIP, glucagon. All these receptors are getting hit at the same time. That is a difference right there than your traditional GLP1s that just suppress your appetite, stop you from eating, and of course, you're going to lose weight. So, now let's talk about the phase 3 trial everyone's talking about and quoting without actually understanding what the hell happened. So, the Triumph 4 was a 68week study with 445 participants. Crazy. And these were just not overweight people. They were overweight with problems with osteoritis. They have chronic inflammation. They have chronic pain. They have long-term metabolic issues. And you can call it dysfunction. They tested two doses, 9 millig and 12 millig weekly. Now, the preface, these are very [ __ ] high doses. At 12 millig, the average weight loss was nearly 28. 7%. That's over 70 lb on average. The 9 mgram group wasn't far behind that. It was 26. 4%. Now, that is insane. But this is what most people are not talking about, the titration of this drug. And they didn't start people at those doses. They didn't rush the dosing. They start everyone at 2 milligrams every week and escalated every four weeks. 2 4 6 9 and then 12 for the highest group. Why the [ __ ] does this matter? Because in phase 2, this is where they made a mistake. Well, not all, but we know now. They tried jumping the doses faster. They started at 4 milligrams, moving way too quickly and the dropout rate were it was crazy. Everyone dropped out because the side effects were double what they were. Now during phase three, the researchers learned from that. Now even with a slower tyration, almost 80% of people on the 12 millig still dropped out from the side effects. Nearly one in five could even tolerate the highest doses. That is telling us something. Higher doses does not automatically mean better or smarter use. Now, here's where the Red True Tide separates itself because other GLP ones can't keep up with it. This was not just about losing weight, which is important. They saw meaningful improvements, and I mean meaningful ones with their HDL, their triglycerides, their CRP markers, and their blood pressure. This tells you that it's different. It's not just suppressing your appetite. It's not just for people with metabolic issues. And here's another really important detail. The fatter that somebody was at their baseline, the better REA worked. The people with more fat lost an average of 26% of body fat. That's crazy. And the leaner participants lost basically 21%. It's still really impressive. It's the same drug, the same dose, but different metabolic starting points. And this is the part that completely changed how I think and look at Reddit now because this trial was done on people with knee arthritis. They had chronic joint pain. They have excessive weight. They have excessive inflammation. And the pain that they were suffering with dropped over 76%. That's unheard of. It's almost 100% guys. Yes, weight loss is going to reduce the mechanical load obviously. But the pain reduction happened faster than the weight loss. That tells us something else is going on here. Red tide is 100% reducing systemic inflammation. I mean directly not because you're losing weight. And that matters a lot when we're talking about application here. Because chronic inflammation is one of the biggest, hardest barriers to cross for fat loss and muscle retention. It destroys your insulin sensitivity. It destroys your hormones and it destroys your recovery. Most diets make inflammation worse when the calories start to drop because you're not recovering now. You have less nutrients. Rea does the opposite. Let me walk you guys through exactly what I was doing over the last 10 weeks. I started around 250 255 252 roughly between that and I was probably 12 to 15% body fat. My goal was not weight loss at all. Right? It was getting back the singledigit body fat while I was not trying to lose muscle. I followed a modified version of the phase 3 titration of rea. I started at 2 milligrams weekly for 2 weeks. Then I moved to 4 milligs weekly for 3 weeks. And then I went to 6 milligrams weekly for another 3 weeks. I tried to stay conservative. I did not push to 9 or 12 milligrams. But the problem is at my body fat level, the returns diminish

Segment 2 (05:00 - 10:00)

really quickly and the side effects jumped up fast. Definitely not smart to use, but I was testing myself. The side effects for me that impacted my lifestyle was the nausea. It was very uncomfortable and I really did not want food the first 10 to 14 days. Now what made the difference was the slow tyration and focusing on protein first during my meals then carbs then fats. Hydration was like very important. I could not drink enough and not forcing food when my appetite was just not there. I was trying to eat something but not overdoing it. My training I had to completely change because when my appetite drops that quickly my recovery is not good and that requires me to be intelligent and make a decision where my volume has to come down. I reduced my training volume probably 40%. My intensity was really high. My rest periods at the gym were very long which typically I don't do at this point. And my cardio went from being stairmaster three, four, five times a week to just walking. I really reduced it. And my strength wasn't too bad. I'm not that strong as it is, so it didn't really drop that much, but I went to a little bit higher rep range, like 12 to 15 versus 10 to 12, 8 to 12. No crazy losses there at all, to be honest with you. My nutrition is always very simple, so that really didn't become an issue. My protein was high for me at least. I went up to like one gram, 1. 5 gram per lean body mass versus a half, maybe a quarter. My carbs were always moderate. They never changed. Going low would have just destroyed everything. My cortisol went up. My performance would have went down. It would have been a mess. My calories were anywhere between 2,000 to 2500 probably. I know it's a big range, but most part that's where it was. The appetite suppression was not to the point of like, you know, starving. I was just satiated like really. I could eat, but I wasn't like, "Oh, I need to eat more or I'm not or I'm still hungry. I need to go have something else or add more food. " This is important because I didn't run the rea solo. And this is I typically think where people lose their muscle. I stacked it with CJC1295 and I permeon because I wanted to make sure my growth hormone stayed elevated and my sleep quality and my recovery stayed very good. Now, BBC has been ran daily for a while for joints, injuries, uh, gut stability, inflammation control, and then I also was layering in GHKCU to support my skin and collagen and connective tissue because when you're losing weight like that, those are the first things to go. And the synergy really matters with these peptides. My sleep needed to stay deep. I don't want my joints hurting. I didn't want to flatten out. And I wanted to make sure my skin elasticity stayed really good when my weight's fluctuating that quickly and that much. Now, after 10 weeks of running this, I got down to 225, 218 at one point. My total loss was over 25 pounds. My body fat was it had to be 78%. I didn't measure it, but I'm going off my eye, which is X-ray vision, which is really accurate. I was lean. I was shredded. Now, the unexpected benefits was my insulin sensitivity, like my A1C went down to under five, which is unheard of. I've never gotten that low in my life. No joint inflammation at all. And I have multiple injuries. my pec, my back, my shoulders, my knees, everything hurts for the most part. It's not uncomfortable, but they hurt. Not at all. And then I had no hunger when I started to rebound out of this come off. But the thing is, if I ran this again, I would stay longer at a lower dose and bring in the growth hormone, like synthetic growth hormone or something stronger like, you know, hexarellin earlier on, not waiting so long. I did it too late. Now, what worked better than expected was the reduction of inflammation and my recovery was still really [ __ ] good. I was not getting sore at all. I felt fine the next day. I could do a full workday. Now, what didn't work as expected was pushing the fat loss once I was already shredded. And I was shredded. The appetite suppression matters less when I got that lean. And no, I was not coming off cold. That'd be crazy and dumb. I tapered off everything slowly because I wanted to bring my calories back up slowly. I wanted to make sure I got labs done so I can track this stuff. And I wanted to keep my metabolic health stabilized. I'm not trying to stay shredded this year round because it's not maintainable. It's not sustainable. I don't feel the best training like this either. Performance in the gym is not good. But the bottom line is reatride even for me is the most powerful fat loss compound I've ever used in my life. And it's the most powerful one I've ever seen in clinical trials. And my personal experimentation with this with clients has been nothing but amazing. But I'm not trying to sell you guys a magic pill cuz it's not. If you push this too hard, you go too fast, you're going to feel [ __ ] terrible and you're going to run into side effects that don't disappear immediately. But if you use it the right way and you stack it properly and you monitor your health, this completely could transform everything in the way we thought about fat loss and transformations overall. Most people are going to grab Retta from a research website. They're not going to know if it's real or not. They're not even going to know if it's a real GLP1 triple agonist. And that's a problem there because if you don't have a real triple one agonist, none of this stuff matters I just told you. They're not going to get blood work done and they're going to wonder why they're losing muscle and they feel like [ __ ] So if you're serious about doing this the right way under medical supervision, there's a

Segment 3 (10:00 - 10:00)

link in the description, book an assessment call with my team. We work with only high performing men who want to get in elite shape without sacrificing their health. So, if you got value from this video, hit subscribe, drop a comment, and tell me what compound you want me to break down yet, next, possibly even use for you guys as a test subject. I'll see you guys in the next

Другие видео автора — Nick Trigili | Biohacking & Performance Specialist

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